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Hyoscine, also known as scopolamine, is a medication used to treat motion sickness and postoperative nausea and vomiting. It is also sometimes used before surgery to decrease saliva. When used by injection, effects begin after about 20 minutes and last for up to 8 hours. It may also be used by mouth and as a dermal patch.

The likelihood of experiencing adverse effects from hyoscine is increased in the elderly relative to younger people. This phenomenon is especially true for older people who are also on several other medications. It is recommended that hyoscine use should be avoided in this age group because of these potent anticholinergic adverse effects.

Hyoscine was used in conjunction with morphine, oxycodone, or other opioids from before 1900 into the 1960s to put mothers in labor into a kind of “twilight sleep”. The analgesia from hyoscine plus a strong opioid is deep enough to allow higher doses to be used as a form of anaesthesia. Hyoscine mixed with oxycodone (Eukodal) and ephedrine was marketed by Merck as SEE (from the German initials of the ingredients) and Scophedal starting in 1928, and the mixture is sometimes mixed on site on rare occasions in the area of its greatest historical usage, namely Germany and Central Europe.

Scopolamine was first clarified in 1881 and started to be used for sedation around 1900. Around this time it was first proposed for and subsequently thusly used from now onward, indefinitely a truly significant time-frame to provoke amnesia and synergistic assistance with distress during work by directing a mix of both scopolamine and morphine. These alkaloids when used in blend prompted a synergistic state called “sunset sleep”. Scopolamine is in like manner the crucially unique part made by unambiguous plants of the nightshade family, which by and large have been used as psychoactive meds (known as deliriants) due to their antimuscarinic-started hallucinogenic effects. The name “scopolamine” is gotten from one kind of nightshade known as Scopolia, while the name “hyoscine” is gotten from another sort known as Hyoscyamus niger. It is on the World Health Organization’s List of Essential Medicines.

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